When liver function is compromised, the precise cause often can be difficult to determine. Supporting the liver is essential if function is to be improved. Administering S-Adenosylmethionine, which is found in Denamarin, has been shown to increase liver glutathione levels, a potent antioxidant formed when cats and dogs metabolize SAMe. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration.

Denamarin also helps support your pet's liver through the administration of silybin. Silybin is the most active part of an extract from milk thistle known as silymarin.

• Silybin/silymarin has been shown to support liver function by acting as an antioxidant.
• Silybin also stimulates the flow of bile through the liver to aid in the digestion and absorption of nutrients from your pet's diet.
• Silybin also helps with liver cell regeneration and may
  enhance levels of glutathione, the liver's major “detoxifying” agent.

Denamarin has no known side-effects and your veterinarian can evaluate the length of support needed through follow-up examinations, blood work, and/or other laboratory work. At home, you can watch for improvements in your pet's attitude, appetite, and activity level.

Frequently Asked Questions

How much Denamarin should I give my pet?
The administration guide below is provided as a general recommendation, but your veterinarian will advise you as to the amount to initially administer. Depending on your pet's response and status, your veterinarian may eventually adjust this amount to meet your pet's individual needs. Remember, Denamarin tablets should not be broken. When increasing or decreasing the administration, adjustments should be done in full tablet increments. Some pets are given Denamarin only for a short period of time, while Denamarin may be used longer periods of time in other animals.

DAILY ADMINISTRATION GUIDE:
FELINE AND CANINE DENAMARIN DAILY* ADMINISTRATION GUIDE

For Cats and Small Dogs

Body Weight		# Tablets
Pounds	Kilograms	One tablet
Up to 12	Up to 5.5

For Medium Dogs

Body Weight		# Tablets
Pounds	Kilograms	One tablet
13 to 34	6 to 15.5

For Large Dogs

Body Weight		# Tablets
Pounds	Kilograms	One tablet
35 to 65	16 to 29.9
66 to 120	30 to 54.5	Two tablets
Over 120	Over 54.5	Three tablets

*The number of tablets can be gradually reduced or increased at any time depending on the pet's needs. Many pets are maintained long-term on every-other-day or every-third-day administration.

How will I know if Denamarin is helping my pet?
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denamarin and how it may help to improve your pet's liver function. At home, watch for improvements in attitude, appetite, and activity level.

Are there any side effects?
There are no known side effects from Denamarin administration and the active ingredients in Denamarin have been shown to be well-tolerated by both dogs and cats with a wide margin of safety.

Can Denamarin™ be used with other products?
Yes, your veterinarian may recommend combining Denamarin with other products, like Marin^®, and/or other dietary modifications. Combining Marin with Denamarin provides added levels of silybin along with vitamin E and zinc for those patients that may benefit from additional liver support. There are no known interactions of Denamarin with drugs or other supplements.

Are other brands the equivalent to Denamarin?
While other S-Adenosylmethionine and silybin products for humans are available individually in health food stores and over-the-counter in pharmacies, there can be a significant variance in product quality and tablet strengths. Denamarin's active ingredients individually have been shown to be safe and effective for both dogs and cats in published research studies and have been combined in a single easy-to-administer tablet. Denamarin also contains a specific silybin shown to provide better bioavailability in dogs compared to the standardized milk thistle commonly available in health food stores and over-the-counter in pharmacies.

Since one of the actives in Denamarin is SAMe and that is made from methionine, should I give my pet methionine?
Administration of methionine is not recommended. Providing high levels of methionine to pets with liver compromise may not increase the production of natural SAMe and has been shown in some cases to increase liver damage.

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.