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Tetracycline
Trade and Other Names
Panmycin, Duramycin powder
Drug Class
Antibacterial
Mechanism of Action and
Clinical Use
Tetracycline antibiotic.
Mechanism of action of tetrecyclines is to bind to 30S ribosomal subunit and
inhibit protein synthesis. Usually bacteriostatic, with broad-spectrum activity,
including bacteria, some protozoa, Rickettsia spp. Used to treat a variety of
infections, including pneumonia and urinary tract infection.
Adverse Effects
Tetracyclines in general may
cause tubular nucrosis at high doses. Tetracyclines can affect bone and teeth
formation in young animals. Tetracyclines have been implicated in drug fever in
cats. Hepatotoxicity may occur at high doses in susceptible individuals.
Contraindications,
Precautions, and Drug Interactions
Do not use in young animals;
it can affect bone and teeth formation. Drug interactions: Tetracyclines bind to
calcium-containing compounds, which decreases oral absorbtion.
Instructions for Use
Pharmacokinetic and
experimental studies have been conducted in small animals, but there have been
no clinical studies. Do not use outdated solutions. Use of tetracyclines has
been replaced primarily by doxycycline.
Small Animal Dosage
Information
(To convert pounds to kilograms: Divide lbs by 2.2. For
the proper dosage, then multiply the mg/kg by the weight kg)
Dogs and Cats: 15-20
mg/kg,q8h,PO; or 4.4-11 mg/kg,q8h,IV,IM